Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system
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چکیده
منابع مشابه
TRP channels as drug targets.
Ca2+ channel antagonists acting on electrically-excitable cells have proved to be valuable therapeutic agents. The discovery of such agents and the identification of their molecular target resulted from the investigation of unexpected actions of known pharmacological agents. Ca2+ influx through receptor-operated channels in electrically non-excitable cells such as leukocytes is also functionall...
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To date, 28 mammalian transient receptor potential (TRP) channels have been cloned and characterized. They are grouped into six subfamilies on the basis of their amino acid sequence homology: TRP Ankyrin (TRPA), TRP Canonical (TRPC), TRP Melastatin (TRPM), TRP Mucolipin (TRPML), TRP Polycystin (TRPP), and TRP Vanilloid (TRPV). Most of the TRP channels are nonselective cation channels expressed ...
متن کاملTransient Receptor Potential (TRP) Channels in the Eye
The first member of transient receptor potential (TRP) channel superfamily was discovered in photoreceptors of Drosophila over 30 years ago.1 Since then this protein superfamily has been extensively characterized based on exponential increases in the number of publications related to TRP channels. With 28 TRP homologous genes identified in mammals, TRP channels have been detected in both neural...
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Cardiac fibrosis is associated with most cardiac diseases. Fibrosis is an accumulation of excessive extracellular matrix proteins (ECM) synthesized by cardiac fibroblasts and myofibroblasts. Fibroblasts are the most prevalent cell type in the heart, comprising 75% of cardiac cells. Myofibroblasts are hardly present in healthy normal heart tissue, but appear abundantly in diseased hearts. Cardia...
متن کاملTRP Channels: Their Function and Potentiality as Drug Targets
The transient receptor potential (TRP) proteins are a family of ion channels that act as cellular sensors as well as signal integrators. Several members of the TRP family are sensitive to changes in cellular redox status. Among them, TRPA1 is remarkably susceptible to various oxidants and is known to mediate neuropathic pain and respiratory, vascular, and gastrointestinal functions, making TRPA...
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ژورنال
عنوان ژورنال: Pharmacology & Therapeutics
سال: 2011
ISSN: 0163-7258
DOI: 10.1016/j.pharmthera.2011.03.006